miRiad roles for the miR-17-92 cluster in development and disease

被引：995

作者：

Mendell, Joshua T. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Dept Pediat, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

来源：

CELL | 2008年 / 133卷 / 02期

关键词：

D O I：

10.1016/j.cell.2008.04.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. New work reveals essential functions for these miRNAs not only in tumor formation but also during normal development of the heart, lungs, and immune system.

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页码：217 / 222

页数：6

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