Liver assist systems: state of the art

被引：46

作者：

Arkadopoulos, N ^{[1
]}

Detry, O ^{[1
]}

Rozga, J ^{[1
]}

Demetriou, AA ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USA

来源：

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | 1998年 / 21卷 / 12期

关键词：

hepatocytes; bioartificial liver; charcoal; hemodialysis; hemoperfusion;

D O I：

10.1177/039139889802101201

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Attempts to develop liver support systems for the treatment of patients with liver failure have ranged from use of plasma exchange to utilization of charcoal columns and extracorporeal devices loaded with liver tissue. However, no system has achieved wide clinical use and - in the absence of liver transplantation - severe hepatic failure continues to be associated with significant morbidity and mortality In this paper, the authors review the current status of liver assist systems and summarize their clinical experience with a xenogeneic cell based-bioartificial liver.

引用

页码：781 / 787

页数：7

共 61 条

[1]

ABOUNA GM, 1972, SURGERY, V71, P537

[2] DEVELOPMENT OF BIOARTIFICIAL LIVER - BILIRUBIN CONJUGATION IN GUNN-RATS [J].