Apoptosis in perinatal hypoxic-ischemic brain injury: How important is it and should it be inhibited?

被引：93

作者：

Northington, FJ

Graham, EM

Martin, LJ

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pediat, Eudowood Neunatal Pulm Div,Dept Pediat, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Gyn Ob, Div Maternal Fetal Med, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21287 USA

[4] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21287 USA

来源：

BRAIN RESEARCH REVIEWS | 2005年 / 50卷 / 02期

关键词：

perinatal brain injury; stroke; hypoxia-ischemia; programmed cell death; cell death continuum; excitotoxicity;

D O I：

10.1016/j.brainresrev.2005.07.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The discovery of safe and effective therapies for perinatal hypoxia-ischemia (HI) and stroke remains an unmet goal of perinatal medicine. Hypothermia and antioxidants Such as allopurinol are Currently under investigation as treatments for neonatal H1. Drugs targeting apoptotic mechanisms are currently being studied in adult diseases such as cancer, stroke, and trauma and have been proposed as potential therapies for perinatal HI and stroke. Before developing antiapoptosis therapies for perinatal brain injury, we must determine whether this form of cell death plays an important role in these injuries and if the inhibition of these pathways promotes more benefit than harm. This review summarizes current evidence for apoptotic mechanisms in perinatal brain injury and addresses issues pertinent to the development of antiapoptosis therapies for perinatal HI and stroke. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：244 / 257

页数：14

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