Regulation of tyrosine kinase cascades by G-protein-coupled receptors

被引：594

作者：

Luttrell, LM

Daaka, Y

Lefkowitz, RJ

机构：

[1] Duke Univ, Howard Hughes Med Inst, Ctr Med, Durham, NC 27710 USA

[2] Duke Univ, Dept Med, Ctr Med, Durham, NC 27710 USA

[3] Duke Univ, Dept Surg, Ctr Med, Durham, NC 27710 USA

[4] Duke Univ, Dept Biochem, Ctr Med, Durham, NC 27710 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(99)80023-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitogenic signaling by G-protein-coupled receptors (GPCRs) involves tyrosine phosphorylation of adaptor proteins and assembly of multiprotein Ras activation complexes. Over the past three years, three types of scaffolds for GPCR-directed complex assembly have been identified: transactivated receptor tyrosine kinases (RTKs), integrin-based focal adhesions, and GPCRs themselves. Nonreceptor tyrosine kinases play an important role in each case. The processes of GPCR desensitization and sequestration via clathrin-coated pits are also involved in signaling through the RTK- and GPCR-based scaffolds.

引用

页码：177 / 183

页数：7

共 56 条

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