Kinin receptors

被引：127

作者：

Marceau, F ^{[1
]}

Bachvarov, DR ^{[1
]}

机构：

[1] CHU Quebec, Ctr Rech, Quebec City, PQ G1R 2J6, Canada

来源：

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY | 1998年 / 16卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1007/BF02737658

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Rapid developments are expected in the molecular pharmacology of both B1, and B2 types of kinin receptors, since the underlying genetic structures are now known and widely studied. The consequences of kinin receptor duality and physiopathological regulation have not yet been fully appreciated. Medicinal chemistry is also an active front of research in kinin pharmacology, as more effective drugs targeted at kinin receptors are regularly reported. Various complementary molecular approaches (the receptor binding, cloning, immunoreacting, mutagenesis, inactivation, the study of regulation, allelic polymorphisms, and so forth) are expanding our knowledge of the role of kinins in allergy, inflammation, and singularly, renal medicine.

引用

收藏

页码：385 / 401

页数：17

相关论文

共 95 条

[1] Efficacy and tolerability of Icatibant (Hoe 140) in patients with moderately severe chronic bronchial asthma [J].

Akbary, AM ;

Wirth, KJ ;

Scholkens, BA .

IMMUNOPHARMACOLOGY, 1996, 33 (1-3) :238-242

[2] Salt-sensitive hypertension in bradykinin B-2 receptor knockout mice [J].

Alfie, ME ;

Yang, XP ;

Hess, F ;

Carretero, OA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 224 (03) :625-630

[3] Extracellular domains of the bradykinin B2 receptor involved in ligand binding and agonist sensing defined by anti-peptide antibodies [J].

Alla, SA ;

Quitterer, U ;

Grigoriev, S ;

Maidhof, A ;

Haasemann, M ;

Jarnagin, K ;

MullerEsterl, W .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (03) :1748-1755

[4]

ALLA SA, 1993, J BIOL CHEM, V268, P17277

[5] On the structure of the amino-terminal domain ED1 of the B2 receptor [J].

Alla, SA ;

Quitterer, U ;

Schroder, C ;

Blaukat, A ;

Horstmeyer, A ;

Dedio, J ;

Reilander, H ;

MullerEsterl, W .

IMMUNOPHARMACOLOGY, 1996, 33 (1-3) :42-45

[6] CONTRACTIONS INDUCED BY ANGIOTENSIN-I, ANGIOTENSIN-II AND BRADYKININ IN ISOLATED SMOOTH-MUSCLE FROM THE HUMAN DETRUSOR [J].

ANDERSSON, KE ;

HEDLUND, H ;

STAHL, M .

ACTA PHYSIOLOGICA SCANDINAVICA, 1992, 145 (03) :253-259

[7] Novel subtype-selective nonpeptide bradykinin receptor antagonists FR167344 and FR173657 [J].

Aramori, I ;

Zenkoh, J ;

Morikawa, N ;

ODonnell, N ;

Asano, M ;

Nakamura, K ;

Iwami, M ;

Kojo, H ;

Notsu, Y .

MOLECULAR PHARMACOLOGY, 1997, 51 (02) :171-176

[8]

Audet R, 1997, J PHARMACOL EXP THER, V280, P6

[9]

Austin CE, 1997, J BIOL CHEM, V272, P11420

[10] REDUCTION BY HOE-140, THE B-2 KININ RECEPTOR ANTAGONIST, OF ANTIGEN-INDUCED NASAL BLOCKAGE [J].

AUSTIN, CE ;

FOREMAN, JC ;

SCADDING, GK .

BRITISH JOURNAL OF PHARMACOLOGY, 1994, 111 (04) :969-971

← 1 2 3 4 5 6 7 8 9 10 →