Dendritic spine geometry: Functional implication and regulation

被引：189

作者：

Hayashi, Y ^{[1
]}

Majewska, AK

机构：

[1] MIT, RIKEN, Neurosci Res Ctr, Cambridge, MA 02139 USA

[2] MIT, Dept Brain & Cognit Sci, Picower Ctr Learning & Memory, Cambridge, MA 02139 USA

来源：

NEURON | 2005年 / 46卷 / 04期

关键词：

D O I：

10.1016/j.neuron.2005.05.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dendritic spines are tiny protrusions on dendritic shafts where most excitatory synapses are located. Recent advances in imaging technologies have given us great insight into the function of spines as biochemical compartments. Here we review recent evidence suggesting that the geometry of dendritic spines controls postsynaptic calcium signaling and is bidirectionally regulated during synaptic plasticity.

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收藏

页码：529 / 532

页数：4

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