Involvement of phospholipids in apolipoprotein B modification during low density lipoprotein oxidation

被引：12

作者：

Karakatsani, AI

Liapikos, TA

Troganis, AN

Tsoukatos, DC ^{[1
]}

机构：

[1] Univ Ioannina, Dept Chem, Biochem Lab, GR-45110 Ioannina, Greece

[2] Univ Ioannina, Dept Chem, NMR Ctr, GR-45110 Ioannina, Greece

来源：

LIPIDS | 1998年 / 33卷 / 12期

关键词：

D O I：

10.1007/s11745-998-0318-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An increased amount of phospholipids remained attached on delipidated apolipoprotein B originated from oxidized low density lipoprotein (LDL). P-31 nuclear magnetic resonance analysis of such apolipoprotein showed an organic phosphorus peak at -0.55 ppm, which suggests the formation of adducts (most probably Schiff bases) of oxidized phospholipids with apolipoprotein B. The above reaction occurs in parallel with the hydrolysis of oxidized phospholipids, catalyzed by the LDL-attached platelet-activating factor acetylhydrolase, and may contribute to the proatherogenic effect of oxidatively modified low density lipoprotein.

引用

页码：1159 / 1162

页数：4

共 27 条

[1]

BARTLETT GR, 1959, J BIOL CHEM, V234, P466

[2]

BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911

[3] SULFHYDRYL CHEMISTRY AND SOLUBILITY PROPERTIES OF HUMAN-PLASMA APOLIPOPROTEIN-B [J].