Exploring Positional candidate genes: Linkage conditional on measured genotype

被引：53

作者：

Almasy, L ^{[1
]}

Blangero, J ^{[1
]}

机构：

[1] SW Fdn Biomed Res, Dept Genet, San Antonio, TX 78245 USA

来源：

BEHAVIOR GENETICS | 2004年 / 34卷 / 02期

关键词：

linkage disequilibrium; linkage; quantitative traits; variance components; association;

D O I：

10.1023/B:BEGE.0000013731.03827.69

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Variance component methods for linkage analysis of quantitative traits are now well established and have been applied with great success. Numerous QTLs influencing both normal variation between individuals and biomedically relevant quantitative risk factors have been localized in recent years. These findings have motivated recent methodological developments focused OD the next step in the analytical process, moving beyond QTL localization by linkage to identifying specific genes and the functional polymorphisms in them that influence the phenotype of interest. In this paper, we describe one approach to exploring positional candidate genes in a region of linkage, linkage analysis conditional on measured genotype. We illustrate the properties of this method using simulated data from Genetic Analysis Workshops 10 and 12 and discuss example applications of this method to human quantitative trait data.

引用

页码：173 / 177

页数：5

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