Three-dimensional structural studies on fragments of fibrinogen and fibrin

被引：28

作者：

Doolittle, RF ^{[1
]}

Spraggon, G ^{[1
]}

Everse, SJ ^{[1
]}

机构：

[1] Univ Calif San Diego, Ctr Mol Genet, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1998年 / 8卷 / 06期

关键词：

D O I：

10.1016/S0959-440X(98)80100-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fibrinogen is a 340 kDa glycoprotein found in the blood plasma of all vertebrates. It is transformed into a fibrin clot by the action of thrombin. Recent X-ray structures of core fragments of both fibrinogen and fibrin have revealed many details about this polymerization event. These include structures of a 30 kDa recombinant gamma C domain, an 86 kDa fragment D from human fibrinogen and a cross-linked double-D fragment from fibrin.

引用

页码：792 / 798

页数：7

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