Ncx, a Hox11 related gene, is expressed in a variety of tissues derived from neural crest cells

被引：47

作者：

Hatano, M

Iitsuka, Y

Yamamoto, H

Dezawa, M

Yusa, S

Kohno, Y

Tokuhisa, T

机构：

[1] CHIBA UNIV,SCH MED,CTR BIOMED SCI,DIV DEV GENET,CHUO KU,CHIBA 260,JAPAN

[2] KOBE UNIV,SCH MED,DEPT OPHTHALMOL,KOBE,HYOGO 650,JAPAN

[3] CHIBA UNIV,SCH MED,DEPT ANAT,CHIBA 260,JAPAN

[4] CHIBA UNIV,SCH MED,DEPT PEDIAT,CHIBA 260,JAPAN

来源：

ANATOMY AND EMBRYOLOGY | 1997年 / 195卷 / 05期

关键词：

homeobox; adrenal glands; sympathetic nerve; dorsal root ganglia; enteric ganglia;

D O I：

10.1007/s004290050061

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

We have isolated the murine homeobox gene (Ncx) that belong to a Hox11 gene family. Expression of the Ncx gene was analyzed in total RNAs from embryos by reverse transcribed polymerase chain reaction (RT-PCR). The mRNA was detected in embryos after 9.5 days of embryogenesis (E9.5) and was maximal at E12.5. The RT-PCR also detected the message in total RNAs from adrenal glands and intestine in adult mice. The expression was further examined in various tissues from embryos by in situ hybridization. It was detected in dorsal root ganglia, cranial nerve ganglia (V, IX, X), enteric nerve ganglia and adrenal glands from embryos between E9.5 and E13.5. Since its expression is restricted to tissues derived from neural crest cells, Ncx may play a role in differentiation and proliferation of neural crest lineage cells.

引用

页码：419 / 425

页数：7

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