Signaling to translational control pathways: Diversity in gene regulation in inflammatory and vascular cells

被引：26

作者：

Lindemann, SW

Weyrich, AS

Zimmerman, GA

机构：

[1] Univ Utah, Program Human Mol Biol & Genet, Eccles Inst Human Genet, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Internal Med, Eccles Inst Human Genet, Salt Lake City, UT 84112 USA

[3] Johannes Gutenberg Univ Mainz, Med Klin 2, D-6500 Mainz, Germany

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2005年 / 15卷 / 01期

关键词：

D O I：

10.1016/j.tcm.2004.10.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The expression of a subset of genes is strongly controlled at translational checkpoints, a major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive outside-in signals to specialized pathways that regulate translation of specific messenger RNAs in a transcript-specific fashion and thereby influence key features of cellular phenotype. These pathways and the expression of proteins that they control may be dysregulated in cardiovascular diseases and are therapeutic targets. (c) 2005, Elsevier Inc.

引用

页码：9 / 17

页数：9

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[1] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].