Autophagy facilitates an IFN-γ response and signal transduction

被引：15

作者：

Chang, Yu-Ping ^{[1
,2
]}

Chen, Chia-Ling ^{[2
]}

Chen, Su-O ^{[1
]}

Lin, Yee-Shin ^{[2
,3
]}

Tsai, Cheng-Chieh ^{[1
,3
,4
]}

Huang, Wei-Ching ^{[1
,3
]}

Wang, Chi-Yun ^{[1
,3
]}

Hsieh, Chia-Yuan ^{[1
]}

Choi, Pui-Ching ^{[1
]}

Lin, Chiou-Feng ^{[1
,2
,3
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Inst Clin Med, Tainan 701, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Dept Microbiol & Immunol, Tainan 701, Taiwan

[3] Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan 701, Taiwan

[4] Chung Hwa Univ Med Technol, Dept Nursing, Tainan 717, Taiwan

来源：

MICROBES AND INFECTION | 2011年 / 13卷 / 11期

关键词：

Autophagy; IFN-gamma; Inflammation; Signal transduction; Immune escape; Microbe; DENGUE VIRUS-INFECTION; SYNTHASE KINASE 3-BETA; GROUP-A STREPTOCOCCUS; TOLL-LIKE RECEPTORS; INTERFERON-GAMMA; MYCOBACTERIUM-TUBERCULOSIS; TYROSINE-PHOSPHATASE; ANTIGEN PRESENTATION; ANTIVIRAL RESPONSES; VIRAL RECOGNITION;

D O I：

10.1016/j.micinf.2011.05.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autophagy, that is directly triggered by invaded pathogens and indirectly triggered by IFN-gamma, acts as a defense by mediating intracellular microbial recognition and clearance. In addition, autophagy contributes to inflammation by facilitating an IFN-gamma response and signal transduction. For immune escape, downregulated autophagy may be a strategy used by microbes. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：888 / 894

页数：7

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