Evidence for a role of phospholipid oxidation products in atherogenesis

被引：149

作者：

Berliner, JA

Subbanagounder, G

Leitinger, N

Watson, AD

Vora, D

机构：

[1] Univ Calif Los Angeles, Sch Med, Med Ctr, Dept Pathol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90095 USA

[3] Univ Vienna, Dept Vasc Biol & Thrombosis Res, A-1010 Vienna, Austria

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2001年 / 11卷 / 3-4期

关键词：

D O I：

10.1016/S1050-1738(01)00098-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is growing evidence for the accumulation of phospholipid oxidation products (some of which can also be formed enzymatically) in several chronic disease processes including atherosclerosis. There also is considerable evidence that enzymes involved in hydrolysis of these phospholipids (present in both lipoproteins and cells) may be important in regulation of atherogenesis. In vitro studies suggest that these lipids can activate vascular it wall cells to states that contribute to the atherosclerotic process. This review, focuses on two types of bioactive phospholipids: phosphatidyl cholines in which the sn-2 fatty acid has been modified by oxidation and lysophosphatidic acid in it which both the sn-2 and sn-3 positions have been modified. The mechanism by which these phospholipid oxidation products activate cells has revealed the presence of several different receptors and signal transduction pathways. (C) 2001, Elsevier Science Inc.

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页码：142 / 147

页数：6

相关论文

共 60 条

[1] Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization [J].

An, SZ ;

Bleu, T ;

Zheng, YH ;

Goetzl, EJ .

MOLECULAR PHARMACOLOGY, 1998, 54 (05) :881-888

[2] Mildly oxidized LDL induces expression of group IIa secretory phospholipase A2 in human monocyte-derived macrophages [J].

Anthonsen, MW ;

Stengel, D ;

Hourton, D ;

Ninio, E ;

Johansen, B .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (05) :1276-1282

[3]

Berliner J, 1997, THROMB HAEMOSTASIS, V78, P195

[4]

Bielicki JK, 1996, J LIPID RES, V37, P1012

[5] The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein [J].

Boullier, A ;

Gillotte, KL ;

Hörkkö, S ;

Green, SR ;

Friedmann, P ;

Dennis, EA ;

Witztum, JL ;

Steinberg, D ;

Quehenberger, O .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (13) :9163-9169

[6] In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant [J].

Combes, V ;

Simon, AC ;

Grau, GE ;

Arnoux, D ;

Camoin, L ;

Sabatier, F ;

Mutin, M ;

Sanmarco, M ;

Sampol, J ;

Dignat-George, F .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (01) :93-102

[7] Oxidized phospholipids activate PPARα in a phospholipase A2-dependent manner [J].

Delerive, P ;

Furman, C ;

Teissier, E ;

Fruchart, JC ;

Duriez, P ;

Staels, B .

FEBS LETTERS, 2000, 471 (01) :34-38

[8] Oxidized LDL and lysophosphatidylcholine stimulate plasminogen activator inhibitor-1 expression in vascular smooth muscle cells [J].

Dichtl, W ;

Stiko, A ;

Eriksson, P ;

Goncalves, I ;

Calara, F ;

Banfi, C ;

Ares, MPS ;

Hamsten, A ;

Nilsson, J .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (12) :3025-3032

[9] Tissue factor expression of human monocytes is suppressed by lysophosphatidylcholine [J].

Engelmann, B ;

Zieseniss, S ;

Brand, K ;

Page, S ;

Lentschat, A ;

Ulmer, AJ ;

Gerlach, E .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (01) :47-53

[10] Random versus selective membrane phospholipid oxidation in apoptosis: Role of phosphatidylserine [J].

Fabisiak, JP ;

Tyurina, YY ;

Tyurin, VA ;

Lazo, JS ;

Kagan, VE .

BIOCHEMISTRY, 1998, 37 (39) :13781-13790

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