Zinc release of Zn7-metallothionein-3 induces fibrillar type amyloid-β aggregates

被引：31

作者：

Durand, Jade ^{[1
,2
]}

Meloni, Gabriele ^{[3
]}

Talmard, Christine ^{[1
,2
]}

Vasak, Milan ^{[3
]}

Faller, Peter ^{[1
,2
]}

机构：

[1] CNRS, LCC, F-31077 Toulouse, France

[2] Univ Toulouse, UPS, INPT, LCC, F-31077 Toulouse, France

[3] Univ Zurich, Dept Biochem, CH-8057 Zurich, Switzerland

来源：

METALLOMICS | 2010年 / 2卷 / 11期

基金：

瑞士国家科学基金会;

关键词：

GROWTH-INHIBITORY FACTOR; METALLOTHIONEIN-III; SYNAPTIC ZINC; METAL; ROLES;

D O I：

10.1039/c0mt00027b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The reactive oxygen species H2O2 promotes the Zn-7-metallothionein-3 induced A beta(40) aggregation of fibrillar type structures via slow cysteine oxidation and Zn2+ release, whereas amorphous aggregates are formed by addition of Zn2+ to A beta(40).

引用

页码：741 / 744

页数：4

共 24 条

[1]

Adlard PA, 2006, J ALZHEIMERS DIS, V10, P145

[2] The Metallothionein/Thionein System: An Oxidoreductive Metabolic Zinc Link [J].

Bell, Stephen G. ;

Vallee, Bert L. .

CHEMBIOCHEM, 2009, 10 (01) :55-62

[3] RAPID INDUCTION OF ALZHEIMER A-BETA AMYLOID FORMATION BY ZINC [J].

BUSH, AI ;

PETTINGELL, WH ;

MULTHAUP, G ;

PARADIS, MD ;

VONSATTEL, JP ;

GUSELLA, JF ;

BEYREUTHER, K ;

MASTERS, CL ;

TANZI, RE .

SCIENCE, 1994, 265 (5177) :1464-1467

[4] S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation [J].

Chen, Y ;

Irie, Y ;

Keung, WM ;

Maret, W .

BIOCHEMISTRY, 2002, 41 (26) :8360-8367

[5] Zinc takes the center stage:: its paradoxical role in Alzheimer's disease [J].

Cuajungco, MP ;

Fagét, KY .

BRAIN RESEARCH REVIEWS, 2003, 41 (01) :44-56

[6] A Role for Synaptic Zinc in Activity-Dependent Aβ Oligomer Formation and Accumulation at Excitatory Synapses [J].

Deshpande, Atul ;

Kawai, Hideki ;

Metherate, Raju ;

Glabe, Charles G. ;

Busciglio, Jorge .

JOURNAL OF NEUROSCIENCE, 2009, 29 (13) :4004-4015

[7] Study on structure-property-reactivity-function relationship of human neuronal growth inhibitory factor (hGIF) [J].

Ding, Zhi-Chun ;

Zheng, Qi ;

Cai, Bin ;

Ni, Feng-Yun ;

Yu, Wen-Hao ;

Teng, Xing-Chen ;

Gao, Yuan ;

Liu, Fang ;

Chen, Dong ;

Wang, Yang ;

Wu, Hou-Ming ;

Sun, Hong-Zhe ;

Zhang, Ming Jie ;

Tan, Xiang-Shi ;

Huang, Zhong-Xian .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2008, 102 (11) :1965-1972

[8] Evidence for a dynamic structure of human neuronal growth inhibitory factor and for major rearrangements of its metal -: Thiolate clusters [J].

Faller, P ;

Hasler, DW ;

Zerbe, O ;

Klauser, S ;

Winge, DR ;

Vasák, M .

BIOCHEMISTRY, 1999, 38 (31) :10158-10167

[9] Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide [J].

Faller, Peter ;

Hureau, Christelle .

DALTON TRANSACTIONS, 2009, (07) :1080-1094

[10]

FREDERICKSON CJ, 1989, INT REV NEUROBIOL, V31, P145

← 1 2 3 →