Anti-inflammatory effects of statins: Clinical evidence and basic mechanisms

被引：753

作者：

Jain, MK

Ridker, PM

机构：

[1] Harvard Univ, Sch Med, Ctr Cardiovasc Dis Prevent, Leduq Ctr Mol & Genet Epidemiol, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Harvard Reynolds Ctr Cardiovasc Res, Boston, MA 02215 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Program Cardiovasc Transcript Biol,Cardiovasc Div, Boston, MA 02115 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2005年 / 4卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrd1901

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chronic inflammation is a key feature of vascular disease states such as atherosclerosis. Multiple clinical studies have shown that a class of medications termed statins lower cardiovascular morbidity and mortality. Originally developed to lower serum cholesterol, increasing evidence suggests that these medications have potent anti-inflammatory effects that contribute to their beneficial effects in patients. Here, we discuss the clinical and experimental evidence underlying the anti-inflammatory effects of these agents.

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页码：977 / 987

页数：11

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