The role of glutathione in the transport and catabolism of nitric oxide

被引：241

作者：

Hogg, N ^{[1
]}

Singh, RJ ^{[1
]}

Kalyanaraman, B ^{[1
]}

机构：

[1] MED COLL WISCONSIN,BIOPHYS RES INST,MILWAUKEE,WI 53226

来源：

FEBS LETTERS | 1996年 / 382卷 / 03期

关键词：

nitric oxide; glutathione; nitrous oxide; peroxynitrite; nitrosothiol;

D O I：

10.1016/0014-5793(96)00086-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide acts as a neuronal and vascular messenger implying diffusion through intracellular environments containing 5-10 mM glutathione. Nitric oxide reacts with glutathione under aerobic conditions generating S-nitrosoglutathione (GSNO). GSNO reacts with glutathione (k = 8.3 x 10(-3) M(-1) . s(-1)) to generate nitrous oxide and glutathione disulfide (GSSG). Anaerobically, glutathione reacts with nitric oxide generating nitrous oxide and GSSG (k = 4.8 x 10(-4) s(-1) at 5 mM GSH). In both aerobic and anaerobic situations the nitroxyl anion may be an intermediate in the synthesis of nitrous oxide and, under aerobic conditions, nitroxyl anion may generate peroxynitrite. We present a hypothesis for the intracellular interaction between nitric oxide and glutathione.

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页码：223 / 228

页数：6

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