Neuroprotection of paclitaxel against cerebral ischemia/reperfusion-induced brain injury through JNK3 signaling pathway

被引：9

作者：

Qi, Su-Hua ^{[1
,2
]}

Zhao, Hui ^{[3
,4
]}

Gong, Juan-Juan ^{[1
,2
]}

Sun, Fu-Mou ^{[5
]}

Yue, Jun ^{[1
,2
]}

Guan, Qiu-Hua ^{[1
,2
]}

Wang, Min ^{[6
]}

机构：

[1] Xuzhou Med Coll, Res Ctr Biochem & Mol Biol, Xuzhou 221002, Peoples R China

[2] Xuzhou Med Coll, Prov Key Lab Brain Dis Bioinformat, Xuzhou 221002, Peoples R China

[3] Nanjing Med Univ, Nanjing Brain Hosp, Dept Neurol, Nanjing, Peoples R China

[4] Xuzhou Cent Hosp, Dept Neurol, Xuzhou, Peoples R China

[5] China Pharmaceut Univ, Sch Pharmaceut Sci, Nanjing 210009, Peoples R China

[6] China Pharmaceut Univ, Sch Life Sci & Biotechnol, Nanjing 210009, Peoples R China

来源：

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION | 2011年 / 31卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Cerebral ischemia; paclitaxel; neuroprotection; c-Jun N-terminal kinase 3 (JNK3); Caspase-3; RAT HIPPOCAMPAL CA1; MAP KINASES; C-JUN; APOPTOSIS; ISCHEMIA; NEURONS; TRANSDUCTION; INHIBITOR; TAXOL;

D O I：

10.3109/10799893.2011.621070

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we investigated the neuroprotective effects of paclitaxel in transient cerebral ischemia and possible regulatory mechanism of these neuroprotection. Our data showed that paclitaxel can down-regulate the increased MLK3, JNK3, c-Jun, Bcl-2, and caspase-3 phosphorylation induced by ischemia injury. Cresyl violet staining and immunohistochemistry results demonstrated that paclitaxel had neuroprotective effect against ischemia/reperfusion-induced neuronal cell death. These results indicated that paclitaxel has neuroprotection in ischemic injury through JNK3 signaling pathway and provided a novel possible drug in therapeutics of brain ischemia.

引用

页码：402 / 407

页数：6

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