A new view of the spindle checkpoint

被引：76

作者：

Hoyt, MA ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA

来源：

JOURNAL OF CELL BIOLOGY | 2001年 / 154卷 / 05期

关键词：

D O I：

10.1083/jcb.200108010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Previous studies of the spindle checkpoint suggested that its ability to prevent entry into anaphase was mediated by the inhibition of the anaphase-promoting complex (APC) ubiquitin ligase by Mad2. Two new studies challenge that view by demonstrating that another checkpoint protein, BubR1, is a far more potent inhibitor of APC function.

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页码：909 / 911

页数：3

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