An endothelial receptor for oxidized low-density lipoprotein

被引:1176
作者
Sawamura, T
Kume, N
Aoyama, T
Moriwaki, H
Hoshikawa, H
Aiba, Y
Tanaka, T
Miwa, S
Katsura, Y
Kita, T
Masaki, T
机构
[1] KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
[2] KYOTO UNIV,FAC MED,DEPT GERIATR MED,KYOTO 606,JAPAN
[3] KYOTO UNIV,CHEST DIS RES INST,DEPT IMMUNOL,KYOTO 606,JAPAN
[4] JAPANESE RED CROSS SAITAMA BRANCH,YONO,SAITAMA 338,JAPAN
关键词
D O I
10.1038/386073a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Endothelial dysfunction or activation elicited by oxidatively modified low-density lipoprotein (Ox-LDL) has been implicated in the pathogenesis of atherosclerosis(1-4), characterized by intimal thickening and lipid deposition in the arteries. Ox-LDL and its lipid constituents impair endothelial production of nitric oxide, and induce the endothelial expression of leukocyte adhesion molecules and smooth-muscle growth factors, which may be involved in atherogenesis(5-7). Vascular endothelial cells in culture(8,9) and in vivo(10,11) internalize and degrade Ox-LDL through a putative receptor-mediated pathway that does not involve macrophage scavenger receptors(12-15). Here we report the molecular cloning, using expression cloning strategy, of an Ox-LDL receptor from vascular endothelial cells. The cloned receptor is a membrane protein that belongs structurally to the C-type lectin family, and is expressed in vivo in vascular endothelium and vascular-rich organs.
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页码:73 / 77
页数:5
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