Yersinia lead SUMO attack

被引：13

作者：

Cornelis, GR

Denecker, G

机构：

[1] Univ Louvain, Christian de Duve Inst Cellular Pathol, Microbial Pathogenesis Unit, B-1200 Brussels, Belgium

[2] Univ Louvain, Fac Med, B-1200 Brussels, Belgium

来源：

NATURE MEDICINE | 2001年 / 7卷 / 01期

关键词：

D O I：

10.1038/83298

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Little is known about the mechanism by which Yops, proteins that Yersinia inject into the cytosol of macrophage, cause downregulation of the inflammatory response and diseases such as the plague. Now it appears that Yops are the first bacterial member of a new family of ubiquitin-like proteases.

引用

页码：21 / 23

页数：3

共 14 条

[1] Role of YopP in suppression of tumor necrosis factor alpha release by macrophages during Yersinia infection [J].

Boland, A ;

Cornelis, GR .

INFECTION AND IMMUNITY, 1998, 66 (05) :1878-1884

[2] Assembly and function of type III secretory systems [J].

Cornelis, GR ;

Van Gijsegem, F .

ANNUAL REVIEW OF MICROBIOLOGY, 2000, 54 :735-774

[3] The bacterial protein YopJ abrogates multiple signal transduction pathways that converge on the transcription factor CREB [J].

Meijer, LK ;

Schesser, K ;

Wolf-Watz, H ;

Sassone-Corsi, P ;

Pettersson, S .

CELLULAR MICROBIOLOGY, 2000, 2 (03) :231-238

[4] Yersinia enterocolitica induces apoptosis in macrophages by a process requiring functional type III secretion and translocation mechanisms and involving YopP, presumably acting as an effector protein [J].

Mills, SD ;

Boland, A ;

Sory, MP ;

vanderSmissen, P ;

Kerbourch, C ;

Finlay, BB ;

Cornelis, GR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (23) :12638-12643

[5] Yersinia-induced apoptosis in vivo aids in the establishment of a systemic infection of mice [J].

Monack, DM ;

Mecsas, J ;

Bouley, D ;

Falkow, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (11) :2127-2137

[6] ASSOCIATION BETWEEN VIRULENCE OF YERSINIA-PESTIS AND SUPPRESSION OF GAMMA-INTERFERON AND TUMOR-NECROSIS-FACTOR-ALPHA [J].

NAKAJIMA, R ;

BRUBAKER, RR .

INFECTION AND IMMUNITY, 1993, 61 (01) :23-31

[7] Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease [J].

Orth, K ;

Xu, ZH ;

Mudgett, MB ;

Bao, ZQ ;

Palmer, LE ;

Bliska, JB ;

Mangel, WF ;

Staskawicz, B ;

Dixon, JE .

SCIENCE, 2000, 290 (5496) :1594-1597

[8] Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector [J].

Orth, K ;

Palmer, LE ;

Bao, ZQ ;

Stewart, S ;

Rudolph, AE ;

Bliska, JB ;

Dixon, JE .

SCIENCE, 1999, 285 (5435) :1920-1923

[9] YopJ of Yersinia pseudotuberculosis is required for the inhibition of macrophage TNF-α production and downregulation of the MAP kinases p38 and JNK [J].

Palmer, LE ;

Hobbie, S ;

Galán, JE ;

Bliska, JB .

MOLECULAR MICROBIOLOGY, 1998, 27 (05) :953-965

[10] YopJ of Yersinia spp. is sufficient to cause downregulation of multiple mitogen-activated protein kinases in eukaryotic cells [J].

Palmer, LE ;

Pancetti, AR ;

Greenberg, S ;

Bliska, JB .

INFECTION AND IMMUNITY, 1999, 67 (02) :708-716

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