Pathophysiological relevance of mitochondria in NAD+ metabolism

被引：139

作者：

Di Lisa, F

Ziegler, M

机构：

[1] Univ Padua, Dipartimento Chim Biol, I-35121 Padua, Italy

[2] Free Univ Berlin, Inst Biochem, D-14195 Berlin, Germany

来源：

FEBS LETTERS | 2001年 / 492卷 / 1-2期

关键词：

permeability transition; myocardial ischemia; cell death; poly(ADP-ribose) polymerase; ADP-ribosylation; cyclic ADP-ribose; oxyradical;

D O I：

10.1016/S0014-5793(01)02198-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pyridine nucleotides are mostly stored within mitochondria where they are involved in different functions ranging from energy metabolism to cellular signaling. Here we discuss the mechanisms of mitochondrial NAD(+) metabolism and release that mag contribute to the crucial roles played by these organelles as triggers or amplifiers of physiological and pathological events. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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页码：4 / 8

页数：5

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