Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase:: Crystal structure of the type IIβ regulatory subunit

被引：118

作者：

Diller, TC

Madhusudan

Xuong, NH

Taylor, SS

机构：

[1] Univ Calif San Diego, Howard Hughes Med Inst, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA

来源：

STRUCTURE | 2001年 / 9卷 / 01期

关键词：

D O I：

10.1016/S0969-2126(00)00556-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Cyclic AMP binding domains possess common structural features yet are diversely coupled to different signaling modules. Each cAMP binding domain receives and transmits a cAMP signal; however, the signaling networks differ even within the same family of regulatory proteins as evidenced by the long-standing biochemical and physiological differences between type I and type II regulatory subunits of cAMP-dependent protein kinase.

引用

收藏

页码：73 / 82

页数：10

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