Oxidative stress in atherosclerosis and diabetes

被引：46

作者：

Lankin, VZ ^{[1
]}

Lisina, MO ^{[1
]}

Arzamastseva, NE ^{[1
]}

Konovalova, GG ^{[1
]}

Nedosugova, LV ^{[1
]}

Kaminnyi, AI ^{[1
]}

Tikhaze, AK ^{[1
]}

Ageev, FT ^{[1
]}

Kukharchuk, VV ^{[1
]}

Belenkov, YN ^{[1
]}

机构：

[1] IM Sechenov Moscow Med Acad, Fac Postgrad Med Training, Dept Endocrinol & Diabet, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2005年 / 140卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

type 2 diabetes mellitus; circulatory insufficiency; low-density lipoproteins; free radical oxidation; autooxidation of cholesterol and glucose;

D O I：

10.1007/s10517-005-0406-z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We measured the content of lipid peroxides in plasma LDL from patients with chronic CHD not accompanied by hypercholesterolemia; CHD and hypercholesterolemia; type 2 diabetes mellitus and decompensation of carbohydrate metabolism; and CHID, circulatory insufficiency, and type 2 diabetes mellitus (without hypercholesterolemia). The content of lipid peroxides in LDL isolated from blood plasma by differential ultracentrifugation in a density gradient was estimated by a highly specific method with modifications (reagent Fe2+ xylene orange and triphenylphosphine as a reducing agent for organic peroxides). The content of lipid peroxides in LDL from patients was much higher than in controls (patients without coronary heart disease and diabetes). Hypercholesterolemia and diabetes can be considered as factors promoting LDL oxidation in vivo. Our results suggest that stimulation of lipid peroxidation in low-density lipoproteins during hypercholesterolemia and diabetes is associated with strong autooxidation of cholesterol and glucose during oxidative and carbonyl (aldehyde) stress, respectively. These data illustrate a possible mechanism of the progression of atherosclerosis in patients with diabetes mellitus.

引用

页码：41 / 43

页数：3

共 14 条

[1] Role of oxidative stress in diabetic complications - A new perspective on an old paradigm [J].

Baynes, JW ;

Thorpe, SR .

DIABETES, 1999, 48 (01) :1-9

[2] LIPID ADVANCED GLYCOSYLATION - PATHWAY FOR LIPID OXIDATION IN-VIVO [J].

BUCALA, R ;

MAKITA, Z ;

KOSCHINSKY, T ;

CERAMI, A ;

VLASSARA, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) :6434-6438

[3] ATHEROSCLEROSIS AND GLYCATION [J].

COLACO, CALS ;

ROSER, BJ .

BIOESSAYS, 1994, 16 (02) :145-147

[4] DIABETES AND CARDIOVASCULAR-DISEASE - FRAMINGHAM-STUDY [J].

KANNEL, WB ;

MCGEE, DL .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1979, 241 (19) :2035-2038

[5]

KLIMOV AN, 1999, NORMAL ABNORMAL META

[6] Glycation and glycoxidation of low-density lipoproteins by glucose and low-molecular mass aldehydes - Formation of modified and oxidized particles [J].

Knott, HM ;

Brown, BE ;

Davies, MJ ;

Dean, RT .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2003, 270 (17) :3572-3582

[7]

LANKIN AZ, 2003, B EKSP BIOL MED, V136, P49

[8]

Lankin VZ, 2004, KARDIOLOGIYA, V44, P72

[9]

Lankin VZ, 2003, NATO SCI SER I LIFE, V344, P8

[10]

Lankin VZ, 2000, KARDIOLOGIYA, V40, P48

← 1 2 →