The Psychiatric GWAS Consortium: Big Science Comes to Psychiatry

被引：177

作者：

Sullivan, Patrick F. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

[2] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden

来源：

NEURON | 2010年 / 68卷 / 02期

关键词：

GENOME-WIDE ASSOCIATION; GENETIC-ASSOCIATION; COMMON VARIANTS; DISEASE; SCHIZOPHRENIA; DISORDERS; PHENOTYPE; ARTICLE;

D O I：

10.1016/j.neuron.2010.10.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Psychiatric GWAS Consortium was founded with the aim of conducting statistically rigorous and comprehensive GWAS meta-analyses for five major psychiatric disorders: ADHD, autism, bipolar disorder, major depressive disorder, and schizophrenia. In the era of GWAS and high-throughput genomics, a major trend has been the emergence of collaborative, consortia approaches. Taking advantage of the scale that collaborative consortia approaches can bring to a problem, the PGC has been a major driver in psychiatric genetics and provides a model for how similar approaches may be applied to other disease communities.

引用

页码：182 / 186

页数：5

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