Quantification of tissue damage in AD using diffusion tensor and magnetization transfer MRI

被引：142

作者：

Bozzali, M

Franceschi, M

Falini, A

Pontesilli, S

Cercignani, M

Magnani, G

Scotti, G

Comi, G

Filippi, M

机构：

[1] Osped San Raffaele, Inst Sci, Dept Neurosci, Neuroimaging Res Unit, I-20132 Milan, Italy

[2] Osped San Raffaele, Inst Sci, Dept Neurosci, Clin Trials Unit, I-20132 Milan, Italy

[3] Osped San Raffaele, Inst Sci, Dept Neuroradiol, I-20132 Milan, Italy

[4] Univ Milan, H San Raffaele, Milan, Italy

[5] Hosp Santa Maria, Dept Neurol, Castellanza, Italy

来源：

NEUROLOGY | 2001年 / 57卷 / 06期

关键词：

D O I：

10.1212/WNL.57.6.1135

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors measured mean diffusivity ((D) over bar) and magnetization transfer ratio (MTR) of the brain from 18 patients with AD and 16 healthy control subjects. The peak heights of cortical gray matter (cGM) (D) over bar (p < 0.001) and MTR (p < 0.001) histograms were lower and average cGM (D) over bar (p < 0.01) higher in patients with AD than in control subjects. A composite MR score based on brain volume and cGM MTR peak height was correlated with patient cognitive impairment (r = 0.65, p = 0.003). This preliminary study presents a novel approach to quantify AD-related tissue damage in-vivo.

引用

页码：1135 / 1137

页数：3

共 10 条

[1] Magnetisation transfer ratio and mean diffusivity of normal appearing white and grey matter from patients with multiple sclerosis [J].