Implicating PARP and NAD+ depletion in type I diabetes

被引:37
作者
Charron, MJ
Bonner-Weir, S
机构
[1] Yeshiva Univ Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
[2] Harvard Univ, Sch Med, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA
关键词
D O I
10.1038/6479
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mice deficient in the PARP DNA repair enzyme are refractory to toxin-induced death of pancreatic beta cells and do not become diabetic (pages 314–319).
引用
收藏
页码:269 / 270
页数:2
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