Implicating PARP and NAD+ depletion in type I diabetes

被引：37

作者：

Charron, MJ

Bonner-Weir, S

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA

[2] Harvard Univ, Sch Med, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

来源：

NATURE MEDICINE | 1999年 / 5卷 / 03期

关键词：

D O I：

10.1038/6479

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mice deficient in the PARP DNA repair enzyme are refractory to toxin-induced death of pancreatic beta cells and do not become diabetic (pages 314–319).

引用

页码：269 / 270

页数：2

共 10 条

[1] Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin [J].

Burkart, V ;

Wang, ZQ ;

Radons, J ;

Heller, B ;

Herceg, Z ;

Stingl, L ;

Wagner, EF ;

Kolb, H .

NATURE MEDICINE, 1999, 5 (03) :314-319

[2] Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia [J].

Eliasson, MJL ;

Sampei, K ;

Mandir, AS ;

Hurn, PD ;

Traystman, RJ ;

Bao, J ;

Pieper, A ;

Wang, ZQ ;

Dawson, TM ;

Snyder, SH ;

Dawson, VL .

NATURE MEDICINE, 1997, 3 (10) :1089-1095

[3] INACTIVATION OF THE POLY(ADP-RIBOSE) POLYMERASE GENE AFFECTS OXYGEN RADICAL AND NITRIC-OXIDE TOXICITY IN ISLET CELLS [J].

HELLER, B ;

WANG, ZQ ;

WAGNER, EF ;

RADONS, J ;

BURKLE, A ;

FEHSEL, K ;

BURKART, V ;

KOLB, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (19) :11176-11180

[4] Apoptosis and the pathogenesis of IDDM - A question of life and death [J].

Mauricio, D ;

Mandrup-Poulsen, T .

DIABETES, 1998, 47 (10) :1537-1543

[5] STZ TRANSPORT AND CYTOTOXICITY - SPECIFIC ENHANCEMENT IN GLUT2-EXPRESSING CELLS [J].

SCHNEDL, WJ ;

FERBER, S ;

JOHNSON, JH ;

NEWGARD, CB .

DIABETES, 1994, 43 (11) :1326-1333

[6] Metabolic fate of glucose in purified islet cells - Glucose-regulated anaplerosis in beta cells [J].

Schuit, F ;

DeVos, A ;

Farfari, S ;

Moens, K ;

Pipeleers, D ;

Brun, T ;

Prentki, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (30) :18572-18579

[7] BIOCHEMICAL-EVIDENCE FOR NITRIC-OXIDE FORMATION FROM STREPTOZOTOCIN IN ISOLATED PANCREATIC-ISLETS [J].

TURK, J ;

CORBETT, JA ;

RAMANADHAM, S ;

BOHRER, A ;

MCDANIEL, ML .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 197 (03) :1458-1464

[8] INTERLEUKIN-1-BETA INDUCES NITRIC-OXIDE PRODUCTION AND INHIBITS THE ACTIVITY OF ACONITASE WITHOUT DECREASING GLUCOSE-OXIDATION RATES IN ISOLATED MOUSE PANCREATIC-ISLETS [J].

WELSH, N ;

SANDLER, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 182 (01) :333-340

[9] PREVENTIVE AND THERAPEUTIC EFFECTS OF LARGE-DOSE NICOTINAMIDE INJECTIONS ON DIABETES ASSOCIATED WITH INSULITIS - AN OBSERVATION IN NON-OBESE DIABETIC (NOD) MICE [J].

YAMADA, K ;

NONAKA, K ;

HANAFUSA, T ;

MIYAZAKI, A ;

TOYOSHIMA, H ;

TARUI, S .

DIABETES, 1982, 31 (09) :749-753

[10] STREPTOZOTOCIN AND ALLOXAN INDUCE DNA STRAND BREAKS AND POLY(ADP-RIBOSE) SYNTHETASE IN PANCREATIC-ISLETS [J].

YAMAMOTO, H ;

UCHIGATA, Y ;

OKAMOTO, H .

NATURE, 1981, 294 (5838) :284-286

← 1 →