The well-tempered vessel

被引：87

作者：

Blau, HM ^{[1
]}

Banfi, A ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Mol Pharmacol, Stanford, CA 94305 USA

来源：

NATURE MEDICINE | 2001年 / 7卷 / 05期

关键词：

D O I：

10.1038/87850

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although gene therapy studies of angiogenesis have focused on the ability of endothelial cells to form new structures, it has recently become clear that the subsequent stages of remodeling are crucial to attaining stable and functional vessels. A precise balance of cell types and molecules is required for normal vessel maturation and must be considered in the design of therapeutic angiogenic strategies.

引用

页码：532 / 534

页数：3

共 16 条

[1] Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal [J].

Benjamin, LE ;

Golijanin, D ;

Itin, A ;

Pode, D ;

Keshet, E .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (02) :159-165

[2] Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis [J].

Bergers, G ;

Brekken, R ;

McMahon, G ;

Vu, TH ;

Itoh, T ;

Tamaki, K ;

Tanzawa, K ;

Thorpe, P ;

Itohara, S ;

Werb, Z ;

Hanahan, D .

NATURE CELL BIOLOGY, 2000, 2 (10) :737-744

[3] Angiogenesis in cancer and other diseases [J].

Carmeliet, P ;

Jain, RK .

NATURE, 2000, 407 (6801) :249-257

[4] Blood vessel maturation: Vascular development comes of age [J].

Darland, DC ;

D'Amore, PA .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (02) :157-158

[5]

Lee RJ, 2000, CIRCULATION, V102, P898

[6] PR39, a peptide regulator of angiogenesis [J].

Li, J ;

Post, M ;

Volk, R ;

Gao, Y ;

Li, M ;

Metais, C ;

Sato, K ;

Tsai, J ;

Aird, W ;

Rosenberg, RD ;

Hampton, TG ;

Li, JY ;

Sellke, F ;

Carmeliet, P ;

Simons, M .

NATURE MEDICINE, 2000, 6 (01) :49-55

[7] Pericyte loss and microaneurysm formation in PDGF-B-deficient mice [J].

Lindahl, P ;

Johansson, BR ;

Leveen, P ;

Betsholtz, C .

SCIENCE, 1997, 277 (5323) :242-245

[8] Angiogenesis gene therapy - Phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease [J].

Rosengart, TK ;

Lee, LY ;

Patel, SR ;

Sanborn, TA ;

Parikh, M ;

Bergman, GW ;

Hachamovitch, R ;

Szulc, M ;

Kligfield, PD ;

Okin, PM ;

Hahn, RT ;

Devereux, RB ;

Post, MR ;

Hackett, NR ;

Foster, T ;

Grasso, TM ;

Lesser, ML ;

Isom, OW ;

Crystal, RG .

CIRCULATION, 1999, 100 (05) :468-474

[9] An address system in the vasculature of normal tissues and tumors [J].

Ruoslahti, E ;

Rajotte, D .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :813-827

[10] Interindividual heterogeneity in the hypoxic regulation of VEGF - Significance for the development of the coronary artery collateral circulation [J].

Schultz, A ;

Lavie, L ;

Hochberg, I ;

Beyar, R ;

Stone, T ;

Skorecki, K ;

Lavie, P ;

Roguin, A ;

Levy, AP .

CIRCULATION, 1999, 100 (05) :547-552

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