Structure/function in neuroprotection and apoptosis

被引：24

作者：

Borden, KLB ^{[1
]}

机构：

[1] CUNY Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA

来源：

ANNALS OF NEUROLOGY | 1998年 / 44卷 / 03期

关键词：

D O I：

10.1002/ana.410440711

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The three-dimensional conformation of proteins influences their potential to function correctly within the cell. Protein conformational issues are particularly important in neurodegeneration, as has been shown by misfolded protein forming the basis of plaques in Alzheimer's disease and prion diseases. This article focuses on protein structure/function specifically for proteins important in the pathogenesis of neurodegenerative conditions and those involved in apoptosis. The proteins used as examples in this review include alpha-synuclein, the promyelocytic leukemia protein, and glyceraldehyde 3-phosphate dehydrogenase.

引用

页码：S65 / S71

页数：7

共 38 条

[1]

[Anonymous], GRASP GRAPHICAL REPR

[2] REFINEMENT OF HUMAN LYSOZYME AT 1.5 A RESOLUTION ANALYSIS OF NONBONDED AND HYDROGEN-BOND INTERACTIONS [J].

ARTYMIUK, PJ ;

BLAKE, CCF .

JOURNAL OF MOLECULAR BIOLOGY, 1981, 152 (04) :737-762

[3] Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis [J].

Booth, DR ;

Sunde, M ;

Bellotti, V ;

Robinson, CV ;

Hutchinson, WL ;

Fraser, PE ;

Hawkins, PN ;

Dobson, CM ;

Radford, SE ;

Blake, CCF ;

Pepys, MB .

NATURE, 1997, 385 (6619) :787-793

[4] An arenavirus RING (zinc-binding) protein binds the oncoprotein promyelocyte leukemia protein (PML) and relocates PML nuclear bodies to the cytoplasm [J].

Borden, KLB ;

Dwyer, EJC ;

Salvato, MS .

JOURNAL OF VIROLOGY, 1998, 72 (01) :758-766

[5] NOVEL TOPOLOGY OF A ZINC-BINDING DOMAIN FROM A PROTEIN INVOLVED IN REGULATING EARLY XENOPUS DEVELOPMENT [J].

BORDEN, KLB ;

LALLY, JM ;

MARTIN, SR ;

OREILLY, NJ ;

ETKIN, LD ;

FREEMONT, PS .

EMBO JOURNAL, 1995, 14 (23) :5947-5956

[6] The promyelocytic leukemia protein PML has a pro-apoptotic activity mediated through its RING domain [J].

Borden, KLB ;

CampbellDwyer, EJ ;

Salvato, MS .

FEBS LETTERS, 1997, 418 (1-2) :30-34

[7] THE SOLUTION STRUCTURE OF THE RING FINGER DOMAIN FROM THE ACUTE PROMYELOCYTIC LEUKEMIA PROTO-ONCOPROTEIN PML [J].

BORDEN, KLB ;

BODDY, MN ;

LALLY, J ;

OREILLY, NJ ;

MARTIN, S ;

HOWE, K ;

SOLOMON, E ;

FREEMONT, PS .

EMBO JOURNAL, 1995, 14 (07) :1532-1541

[8]

Creighton TE, 1993, PROTEINS STRUCTURES

[9] Protein alchemy: Changing beta-sheet into alpha-helix [J].

Dalal, S ;

Balasubramanian, S ;

Regan, L .

NATURE STRUCTURAL BIOLOGY, 1997, 4 (07) :548-552

[10]

Funahashi J, 1996, J BIOCHEM, V120, P1216

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