HATs on and beyond chromatin

被引：150

作者：

Chen, HW ^{[1
]}

Tini, M

Evans, RM

机构：

[1] Univ Calif Davis, Ctr Canc, Basic Sci Program, Dept Biol Chem, Sacramento, CA 95817 USA

[2] Salk Inst Biol Studies, Howard Hughes Med Inst, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(00)00200-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The role of histone acetylation as a key mechanism of transcriptional regulation has been well established. Recent advances suggest that histone acetyltransferases also play important roles in histone-modulated processes such as DNA replication, recombination and repair. In addition, acetylation of transcriptional cofactors and other proteins is an efficient means of regulating a diverse range of molecular interactions As new histone acetyltransferases and substrates are rapidly emerging, it is becoming apparent that protein acetylation may rival phosphorylation as a mechanism to transduce cellular regulatory signals.

引用

页码：218 / 224

页数：7

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