Neurosteroids:: Endogenous regulators of the GABAA receptor

被引：936

作者：

Belelli, D ^{[1
]}

Lambert, JJ ^{[1
]}

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Inst Neurosci, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland

来源：

NATURE REVIEWS NEUROSCIENCE | 2005年 / 6卷 / 07期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrn1703

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GABA(A) (gamma-aminobutyric acid type A) receptors mediate most of the ' fast' synaptic inhibition in the mammalian brain and are targeted by many clinically important drugs. Certain naturally occurring pregnane steroids can potently and specifically enhance GABA(A) receptor function in a nongenomic ( direct) manner, and consequently have anxiolytic, analgesic, anticonvulsant, sedative, hypnotic and anaesthetic properties. These steroids not only act as remote endocrine messengers, but also can be synthesized in the brain, where they modify neuronal activity locally by modulating GABA(A) receptor function. Such ' neurosteroids' can influence mood and behaviour in various physiological and pathophysiological situations, and might contribute to the behavioural effects of psychoactive drugs.

引用

页码：565 / 575

页数：11

共 122 条

[1] Neuroactive steroids have multiple actions to potentiate GABAA receptors [J].