Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: Peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach

被引:469
作者
Bays, H
Mandarino, L
DeFronzo, RA
机构
[1] Univ Texas, Hlth Sci Ctr, Diabet Div, San Antonio, TX 78229 USA
[2] Louisville Metab & Atherosclerosis Res Ctr, Louisville, KY 40213 USA
关键词
D O I
10.1210/jc.2003-030723
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:463 / 478
页数:16
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共 328 条
[1]   ACUTE AND CHRONIC RESPONSES OF SKELETAL-MUSCLE TO ENDURANCE AND SPRINT EXERCISE - A REVIEW [J].
ABERNETHY, PJ ;
THAYER, R ;
TAYLOR, AW .
SPORTS MEDICINE, 1990, 10 (06) :365-389
[2]   Activators of peroxisome proliferator-activated receptor γ have depot-specific effects on human preadipocyte differentiation [J].
Adams, M ;
Montague, CT ;
Prins, JB ;
Holder, JC ;
Smith, SA ;
Sanders, L ;
Digby, JE ;
Sewter, CP ;
Lazar, MA ;
Chatterjee, VKK ;
O'Rahilly, S .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (12) :3149-3153
[3]  
Albu JB, 2000, ANN NY ACAD SCI, V904, P491
[4]   Plasminogen activator inhibitor 1, transforming growth factor-β1, and BMI are closely associated in human adipose tissue during morbid obesity [J].
Alessi, MC ;
Bastelica, D ;
Morange, P ;
Berthet, B ;
Leduc, I ;
Verdier, M ;
Geel, O ;
Juhan-Vague, I .
DIABETES, 2000, 49 (08) :1374-1380
[5]   Production of plasminogen activator inhibitor 1 by human adipose tissue - Possible link between visceral fat accumulation and vascular disease [J].
Alessi, MC ;
Peiretti, F ;
Morange, P ;
Henry, M ;
Nalbone, G ;
JuhanVague, I .
DIABETES, 1997, 46 (05) :860-867
[6]   Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes [J].
Arioglu, E ;
Duncan-Morin, J ;
Sebring, N ;
Rother, KI ;
Gottlieb, N ;
Lieberman, J ;
Herion, D ;
Kleiner, DE ;
Reynolds, J ;
Premkumar, A ;
Sumner, AE ;
Hoofnagle, J ;
Reitman, ML ;
Taylor, SI .
ANNALS OF INTERNAL MEDICINE, 2000, 133 (04) :263-274
[7]   Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity [J].
Arita, Y ;
Kihara, S ;
Ouchi, N ;
Takahashi, M ;
Maeda, K ;
Miyagawa, J ;
Hotta, K ;
Shimomura, I ;
Nakamura, T ;
Miyaoka, K ;
Kuriyama, H ;
Nishida, M ;
Yamashita, S ;
Okubo, K ;
Matsubara, K ;
Muraguchi, M ;
Ohmoto, Y ;
Funahashi, T ;
Matsuzawa, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) :79-83
[8]  
Arner P, 2001, BIOCHEM SOC T, V29, P72, DOI 10.1042/bst0290072
[9]   Regional adipocity in man [J].
Arner, P .
JOURNAL OF ENDOCRINOLOGY, 1997, 155 (02) :191-192
[10]   Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes - A 6-month randomized placebo-controlled dose-response study [J].
Aronoff, S ;
Rosenblatt, S ;
Braithwaite, S ;
Egan, JW ;
Mathisen, AL ;
Schneider, RL .
DIABETES CARE, 2000, 23 (11) :1605-1611