Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21

被引：144

作者：

Matarin, Mar ^{[1
]}

Brown, W. Mark ^{[2
]}

Singleton, Andrew ^{[1
]}

Hardy, John A. ^{[3
]}

Meschia, James F. ^{[4
]}

机构：

[1] NIA, Mol Genet Unit, Neurogenet Lab, Natl Inst Hlth,Porter Neurosci Res Ctr, Bethesda, MD 20892 USA

[2] Wake Forest Univ Hlth Sci, Biostat Sect, Dept Publ Hlth Sci, Winston Salem, NC 27109 USA

[3] UCL, Reta Lila Weston Inst Neurol Studies, Neurol Inst, London WC1E 6BT, England

[4] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA

来源：

STROKE | 2008年 / 39卷 / 05期

基金：

英国医学研究理事会;

关键词：

ischemic stroke; genetics; heart disease; diabetes;

D O I：

10.1161/STROKEAHA.107.502963

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose - Recently independent studies reported an association between coronary heart disease and single-nucleotide polymorphisms (SNPs) located at chromosome 9p21, near CDKN2A and CDKN2B genes. Given that stroke is a common complication after myocardial infarction, we investigated if the same SNPs were associated with ischemic stroke in our population. Methods - We recently initiated a whole genome analysis of ischemic stroke and published the first stage of a case control study using > 400 000 SNPs from Illumina Infinium Human-1 and HumanHap300 assays. We focused on SNPs recently associated with heart disease by Helgadottir and colleagues and SNPs from the same haplotype block. Results - In analyses both unadjusted and adjusted for stroke risk factors, significant associations with ischemic stroke were observed for SNPs from the same haplotype block previously associated with myocardial infarction. Significant association was also seen between disease and haplotypes involving these SNPs, both with and without adjustment for stroke risk factors (odd ratios: 1.01 to 2.65). Conclusions - These data are important for 3 reasons: first, they suggest a genetic association for stroke; second, they suggest that this association shares pathogenic mechanisms with heart disease and diabetes; and third, they illustrate, that public release of data can facilitate rapid risk locus discovery.

引用

页码：1586 / 1589

页数：4

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