Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic

被引：171

作者：

Ahmed, Rafi ^{[1
]}

Oldstone, Michael B. A.

Palese, Peter

机构：

[1] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

[3] Scripps Res Inst, Viral Immunobiol Lab, Mol & Integrat Neurosci Lab, La Jolla, CA 92037 USA

[4] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA

[5] Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA

来源：

NATURE IMMUNOLOGY | 2007年 / 8卷 / 11期

关键词：

D O I：

10.1038/ni1530

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The influenza pandemic of 1918 killed nearly 50 million people worldwide and was characterized by an atypical W-shaped mortality curve, where adults between the ages of 30-60 years fared better than younger adults aged 18-30 years. In this review, we will discuss why this influenza virus strain was so virulent and how immunological memory to the 1918 virus may have shaped the W mortality curve. We will end on the topic of the 'honeymoon' period of infectious diseases - the clinically documented period between the ages of 4-13 years during which children demonstrate less morbidity and/or mortality to infectious diseases, in general, compared with young adults.

引用

页码：1188 / 1193

页数：6

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