Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic

被引:171
作者
Ahmed, Rafi [1 ]
Oldstone, Michael B. A.
Palese, Peter
机构
[1] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA
[2] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA
[3] Scripps Res Inst, Viral Immunobiol Lab, Mol & Integrat Neurosci Lab, La Jolla, CA 92037 USA
[4] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA
[5] Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA
关键词
D O I
10.1038/ni1530
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The influenza pandemic of 1918 killed nearly 50 million people worldwide and was characterized by an atypical W-shaped mortality curve, where adults between the ages of 30-60 years fared better than younger adults aged 18-30 years. In this review, we will discuss why this influenza virus strain was so virulent and how immunological memory to the 1918 virus may have shaped the W mortality curve. We will end on the topic of the 'honeymoon' period of infectious diseases - the clinically documented period between the ages of 4-13 years during which children demonstrate less morbidity and/or mortality to infectious diseases, in general, compared with young adults.
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收藏
页码:1188 / 1193
页数:6
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