Relationship between plasma leptin levels and the tumor necrosis factor-α system in obese subjects

被引:111
作者
Corica, F
Allegra, A
Corsonello, A
Buemi, M
Calapai, G
Ruello, A
Mauro, VN
Ceruso, D
机构
[1] Univ Messina Policlin, Sch Med, Dept Internal Med, Div Internal Med & Metab Dis,Outpatients Serv Pre, I-98124 Messina, Italy
[2] Univ Messina, Sch Med, Inst Pharmacol, I-98122 Messina, Italy
关键词
leptin; TNF alpha; TNF receptors; obesity;
D O I
10.1038/sj.ijo.0800826
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE: To evaluate the relationship between plasma leptin and the tumor necrosis factor-alpha (TNF alpha), TNF receptor pen (TNF-R1) and TNF receptor p80 (TNF-R2) concentrations in obese subjects. DESIGN: Case-control study. SETTING: Outpatient's Service for Prevention and Treatment of Obesity at the University Hospital. MEASUREMENTS: Body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio (WHR), fasting plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance (HOMA IR), plasma leptin, TNF alpha, TNF-R1 and TNF-RS concentrations were evaluated in obese subjects (n = 42) and in age- and gender-matched, lean healthy controls (n = 16). RESULTS: In obese subjects, fasting plasma glucose and insulin, HOMA IR, plasma leptin, TNF alpha, TNF-R1 and TNF-R2 concentrations were significantly higher than in controls. Furthermore, females showed higher leptin, TNF-R1 and TNF-R2 plasma concentrations compared to males, in both control and obese subjects. In control subjects, plasma leptin concentrations showed a direct correlation with BMI (r=0.74, P<0.001), hip circumference (r=0.94, P<0.001), TNF-R1 (r=0.79, P<0.001) and TNF-R2 (r=0.64, P<0.01), and a negative correlation with WHR (r=-0.58, P<0.05). In obese subjects, we found a direct correlation between plasma leptin concentrations and BMI (r=0.67, P<0.001), hip circumference (r=0.66, P<0.001), fasting glucose (r=0.37, P<0.05), fasting insulin (r=0.31, P<0.05), HOMA IR (r=0.38, P<0.05), TNF-R1 (r=0.71, P<0.001) and TNR-R2 (r=0.66, P<0.001), while a negative correlation was found between circulating leptin and WHR (r=-0.44, P<0.01), In multivariate analysis, plasma leptin concentrations were significantly associated with BMI (P=0.015) and gender (P=0.047) in the control group, while in obese subjects, plasma leptin showed a significant association with BMI (P=0.019) and TNF-R1 (P=0.012). CONCLUSIONS: Our results are consistent with the hypothesis that the TNF alpha system could be involved in the regulation of plasma leptin concentrations in obese subjects.
引用
收藏
页码:355 / 360
页数:6
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