Apoptosis in lupus pathogenesis

被引：13

作者：

Greidinger, EL ^{[1
]}

机构：

[1] Univ Missouri, Hlth Sci Ctr MA427, Div Rheumatol & Immunol, Columbia, MO 65212 USA

来源：

FRONTIERS IN BIOSCIENCE | 2001年 / 6卷

关键词：

lupus; apoptosis; autoimmunity; review;

D O I：

10.2741/Greidinger

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis has been implicated in lupus pathogenesis in at least three different ways. As antigen, apoptotic material drives autoimmune responses. As immune modulator, impaired apoptosis makes patients susceptible to developing autoimmunity. As effector mechanism, apoptosis participates in target organ injury. This review summarizes the evidence that links apoptosis to these components of lupus pathogenesis.

引用

页码：D1392 / D1402

页数：11

共 128 条

[1] Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes [J].

Albert, ML ;

Pearce, SFA ;

Francisco, LM ;

Sauter, B ;

Roy, P ;

Silverstein, RL ;

Bhardwaj, N .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (07) :1359-1368

[2] Granzyme B directly and efficiently cleaves several downstream caspase substrates: Implications for CTL-induced apoptosis [J].

Andrade, F ;

Roy, S ;

Nicholson, D ;

Thornberry, N ;

Rosen, A ;

Casciola-Rosen, L .

IMMUNITY, 1998, 8 (04) :451-460

[3]

Arbuckle MR, 1999, SCAND J IMMUNOL, V50, P447

[4] TNF neutralization in MS - Results of a randomized, placebo-controlled multicenter study [J].

Arnason, BGW ;

Jacobs, G ;

Hanlon, M ;

Clay, BH ;

Noronha, ABC ;

Auty, A ;

Davis, B ;

Nath, A ;

Bouchard, JP ;

Belanger, C ;

Gosselin, F ;

Thibault, M ;

Duquette, P ;

Bourgoin, P ;

DuBois, R ;

Girard, M ;

Ebers, GC ;

Rice, GPA ;

Vandervoort, MK ;

Francis, GS ;

Duncan, L ;

Lapierre, Y ;

Freedman, MS ;

Christie, SN ;

Rabinovitch, HE ;

Patry, D ;

Murphy, WF ;

Peters, S ;

McGuiness, SD ;

Murray, TJ ;

Bhan, V ;

Maxner, CE ;

Van Dorpe, R ;

Oger, JJ ;

Nelson, J ;

Morrison, W ;

Bogle, N ;

Beall, S ;

Vorobeychick, G ;

Hiltbrunner, AV ;

Bock, J ;

Habil ;

Lesslauer, W ;

Li, DKB ;

Paty, DW ;

Zhao, GJ .

NEUROLOGY, 1999, 53 (03) :457-465

[5] Catastrophic antiphospholipid syndrome [J].

Asherson, RA ;

Cervera, R .

CURRENT OPINION IN HEMATOLOGY, 2000, 7 (05) :325-329

[6] The combination of apoptotic U937 cells and lupus IgG is a potent IFN-α inducer [J].

Båve, U ;

Alm, GV ;

Rönnblom, L .

JOURNAL OF IMMUNOLOGY, 2000, 165 (06) :3519-3526

[7]

BIAS WB, 1986, AM J HUM GENET, V39, P584

[8] ANALYSIS OF AUTOANTIBODIES TO RECOMBINANT LA (SS-B) PEPTIDES IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND PRIMARY SJOGRENS SYNDROME [J].

BINI, P ;

CHU, JL ;

OKOLO, C ;

ELKON, K .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (02) :325-333

[9] Apoptotic vascular endothelial cells become procoagulant [J].

Bombeli, T ;

Karsan, A ;

Tait, JF ;

Harlan, JM .

BLOOD, 1997, 89 (07) :2429-2442

[10] Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies [J].

Botto, M ;

Dell'Agnola, C ;

Bygrave, AE ;

Thompson, EM ;

Cook, HT ;

Petry, F ;

Loos, M ;

Pandolfi, PP ;

Walport, MJ .

NATURE GENETICS, 1998, 19 (01) :56-59

← 1 2 3 4 5 6 7 8 9 10 →