Appearance of new lesions in two nonfamilial cerebral cavernoma patients

被引:23
作者
Labauge, P
Brunereau, L
Coubes, P
Clanet, M
Tannier, C
Laberge, S
Lévy, C
机构
[1] Fac Med Lariboisiere, Lab Genet Malad Vasc, F-75010 Paris, France
[2] CHU Bretonneau, Serv Radiol Adultes, F-37044 Tours, France
[3] CHU Gui de Chauliac, Serv Neurochirurg, Montpellier, France
[4] CHU Purpan, Serv Neurol, Toulouse, France
[5] CH A Gayraud, Serv Neurol, Carcassonne, France
[6] CHU St Antoine, Serv Radiol, Paris, France
关键词
cavernous angiomas; de novo lesions;
D O I
10.1159/000052100
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Cavernomas are vascular malformations mostly observed in the central nervous system. They occur in sporadic and familial forms. Familiar forms are characterized by the presence of multiple lesions, an autosomal dominant pattern of inheritance and possible de novo lesions. We report two sporadic cases whose follow-up showed the appearance of new lesions. Copyright (C) 2001 S, Karger AG. Basel.
引用
收藏
页码:83 / 88
页数:6
相关论文
共 20 条
[1]   Multilocus linkage identifies two new loci for a Mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and 3q25.2-27 [J].
Craig, HD ;
Günel, M ;
Cepeda, O ;
Johnson, EW ;
Ptacek, L ;
Steinberg, GK ;
Ogilvy, CS ;
Berg, MJ ;
Crawford, SC ;
Scott, RM ;
Steichen-Gersdorf, E ;
Sabroe, R ;
Kennedy, CTC ;
Mettler, G ;
Beis, MJ ;
Fryer, A ;
Awad, IA ;
Lifton, RP .
HUMAN MOLECULAR GENETICS, 1998, 7 (12) :1851-1858
[2]   AN ANALYSIS OF THE NATURAL-HISTORY OF CAVERNOUS ANGIOMAS [J].
DELCURLING, O ;
KELLY, DL ;
ELSTER, AD ;
CRAVEN, TE .
JOURNAL OF NEUROSURGERY, 1991, 75 (05) :702-708
[3]   A GENE RESPONSIBLE FOR CAVERNOUS MALFORMATIONS OF THE BRAIN MAPS TO CHROMOSOME 7Q [J].
DUBOVSKY, J ;
ZABRAMSKI, JM ;
KURTH, J ;
SPETZLER, RF ;
RICH, SS ;
ORR, HT ;
WEBER, JL .
HUMAN MOLECULAR GENETICS, 1995, 4 (03) :453-458
[4]   Familial cerebral cavernous angioma: A gene localized to a 15-cM interval on chromosome 7q [J].
GilNagel, A ;
Dubovsky, J ;
Wilcox, KJ ;
Stewart, JM ;
Anderson, VE ;
Leppik, IE ;
Orr, HT ;
Johnson, EW ;
Weber, JL ;
Rich, SS .
ANNALS OF NEUROLOGY, 1996, 39 (06) :807-810
[5]   A founder mutation as a cause of cerebral cavernous malformation in Hispanic Americans [J].
Gunel, M ;
Awad, IA ;
Finberg, K ;
Anson, JA ;
Steinberg, GR ;
Batjer, PH ;
Kopitnik, TA ;
Morrison, L ;
Giannotta, SL ;
NelsonWilliams, C ;
Lifton, RP .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (15) :946-951
[6]   MAPPING A GENE CAUSING CEREBRAL CAVERNOUS MALFORMATION TO 7Q11.2-Q21 [J].
GUNEL, M ;
AWAD, IA ;
ANSON, J ;
LIFTON, RP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (14) :6620-6624
[7]   FAMILIAL CAVERNOUS ANGIOMAS - NATURAL-HISTORY AND GENETIC-STUDY OVER A 5-YEAR PERIOD [J].
HAYMAN, LA ;
EVANS, RA ;
FERRELL, RE ;
FAHR, LM ;
OSTROW, P ;
RICCARDI, VM .
AMERICAN JOURNAL OF MEDICAL GENETICS, 1982, 11 (02) :147-160
[8]   REFINED LOCALIZATION OF THE CEREBRAL CAVERNOUS MALFORMATION GENE (CCM1) TO A 4-CM INTERVAL OF CHROMOSOME 7Q CONTAINED IN A WELL-DEFINED YAC CONTIG [J].
JOHNSON, EW ;
IYER, LM ;
RICH, SS ;
ORR, HT ;
GILNAGEL, A ;
KURTH, JH ;
ZABRAMSKI, JM ;
MARCHUK, DA ;
WEISSENBACH, J ;
CLERICUZIO, CL ;
DAVIS, LE ;
HART, BL ;
GUSELLA, JF ;
KOSOFSKY, BE ;
LOUIS, DN ;
MORRISON, LA ;
GREEN, ED ;
WEBER, JL .
GENOME RESEARCH, 1995, 5 (04) :368-380
[9]   THE NATURAL-HISTORY OF CEREBRAL CAVERNOUS MALFORMATIONS [J].
KONDZIOLKA, D ;
LUNSFORD, LD ;
KESTLE, JRW .
JOURNAL OF NEUROSURGERY, 1995, 83 (05) :820-824
[10]   Hereditary cerebral cavernous angiomas: clinical and genetic features in 57 French families [J].
Labauge, P ;
Laberge, S ;
Brunereau, L ;
Levy, C ;
Tournier-Lasserve, E .
LANCET, 1998, 352 (9144) :1892-1897