Conservation of gene order: a fingerprint of proteins that physically interact

被引：764

作者：

Dandekar, T

Snel, B

Huynen, M

Bork, P

机构：

[1] European Mol Biol Lab, D-69012 Heidelberg, Germany

[2] Max Delbruck Ctr Mol Med, D-13122 Berlin, Germany

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 09期

关键词：

D O I：

10.1016/S0968-0004(98)01274-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A systematic comparison of nine bacterial and archaeal genomes reveals a low level of gene-order (and operon architecture) conservation. Nevertheless, a number of gene pairs are conserved. The proteins encoded by conserved gene pairs appear to interact physically. This observation can therefore be used to predict functions of, and interactions between, prokaryotic gene products.

引用

页码：324 / 328

页数：5

共 45 条

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