Early 1H magnetic resonance spectroscopy of acute head injury: Four cases

被引:42
作者
Condon, B [1 ]
Oluoch-Olunya, D
Hadley, D
Teasdale, G
Wagstaff, A
机构
[1] So Gen Hosp, Inst Neurol Sci, MRI Unit, Dept Clin Phys, Glasgow G51 4TF, Lanark, Scotland
[2] So Gen Hosp, Inst Neurol Sci, Dept Neurosurg, Glasgow G51 4TF, Lanark, Scotland
[3] So Gen Hosp, Inst Neurol Sci, Dept Neuroradiol, Glasgow G51 4TF, Lanark, Scotland
[4] So Gen Hosp, Inst Neurol Sci, Dept Neuroanaesthesia, Glasgow G51 4TF, Lanark, Scotland
关键词
brain; head injuries; lactates; magnetic resonance spectroscopy; nuclear magnetic resonance;
D O I
10.1089/neu.1998.15.563
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
In an attempt to examine in vivo the early metabolic consequences of severe acute head injury, 1H MRS was performed in four patients from 8 to 25 h (mean 15 h) following trauma. In three of these patients, decompressive surgery was performed 4-5 h prior to the MRS. High levels of lactate (area of lactate peak >50% of the mean areas of the NAA, choline-containing, and creatine-containing compound peaks) were found at 8 h posttrauma in the one patient who was not operated on and at 10 h posttrauma in one of the patients who underwent surgery. In the other two postoperative patients, at 18 and 25 h after trauma, lactate levels were found to be low (lactate peak <20% of the mean area of the other three peaks). In the one patient who had a follow-up at 6 days and who had the largest initial lactate levels, these remained high. These findings suggest that high levels of lactate may not be an inevitable consequence of severe head injury and that similar MRS studies should be performed on each individual patient before therapies to reduce lactate are considered. There appeared to be no correlation between the relative amounts of lactate and outcome.
引用
收藏
页码:563 / 571
页数:9
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