Biological action of leptin as an angiogenic factor

被引：1155

作者：

Sierra-Honigmann, MR

Nath, AK

Murakami, C

García-Cardeña, G

Papapetropoulos, A

Sessa, WC

Madge, LA

Schechner, JS

Schwabb, MB

Polverini, PJ

Flores-Riveros, JR

机构：

[1] Yale Univ, Sch Med, Boyer Ctr Mol Med, New Haven, CT 06536 USA

[2] Univ Michigan, Sch Dent, Dept Oral Med Pathol Surg, Ann Arbor, MI 48109 USA

[3] Bayer Corp, Inst Metab Disorders, West Haven, CT 06516 USA

来源：

SCIENCE | 1998年 / 281卷 / 5383期

关键词：

D O I：

10.1126/science.281.5383.1683

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Leptin is a hormone that regulates food intake, and its receptor (OB-Rb) is expressed primarily in the hypothalamus. Here, it is shown that OB-Rb is also expressed in human vasculature and in primary cultures of human endothelial coils, In vitro and in vivo assays revealed that Leptin has angiogenic activity. In vivo, Leptin induced neovascularization in corneas from normal rats but not in corneas from fa/fa Zucker rats, which Lack functional Leptin receptors. These observations indicate that the vascular endothelium is a target for Leptin and suggest a physiological mechanism whereby Leptin-induced angiogenesis may facilitate increased energy expenditure.

引用

收藏

页码：1683 / 1686

页数：4

相关论文

共 25 条

[1] ASSAYS FOR ANGIOGENESIS - A REVIEW [J].

AUERBACH, R ;

AUERBACH, W ;

POLAKOWSKI, I .

PHARMACOLOGY & THERAPEUTICS, 1991, 51 (01) :1-11

[2] The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors [J].

Baumann, H ;

Morella, KK ;

White, DW ;

Dembski, M ;

Bailon, PS ;

Kim, HK ;

Lai, CF ;

Tartaglia, LA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) :8374-8378

[3] RECOMBINANT MOUSE OB PROTEIN - EVIDENCE FOR A PERIPHERAL SIGNAL LINKING ADIPOSITY AND CENTRAL NEURAL NETWORKS [J].

CAMPFIELD, LA ;

SMITH, FJ ;

GUISEZ, Y ;

DEVOS, R ;

BURN, P .

SCIENCE, 1995, 269 (5223) :546-549

[4]

Castle VP, 1997, LAB INVEST, V77, P51

[5] A review of the microcirculation of adipose tissue: Anatomic, metabolic and angiogenic perspectives [J].

Crandall, DL ;

Hausman, GJ ;

Kral, JG .

MICROCIRCULATION-LONDON, 1997, 4 (02) :211-232

[6] PITUITARY FOLLICULAR CELLS SECRETE A NOVEL HEPARIN-BINDING GROWTH-FACTOR SPECIFIC FOR VASCULAR ENDOTHELIAL-CELLS [J].

FERRARA, N ;

HENZEL, WJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 161 (02) :851-858

[7] Leptin expression and action: New experimental paradigms [J].

Flier, JS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (09) :4242-4245

[8] EXPRESSION OF OB MESSENGER-RNA AND ITS ENCODED PROTEIN IN RODENTS - IMPACT OF NUTRITION AND OBESITY [J].

FREDERICH, RC ;

LOLLMANN, B ;

HAMANN, A ;

NAPOLITANOROSEN, A ;

KAHN, BB ;

LOWELL, BB ;

FLIER, JS .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (03) :1658-1663

[9] Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells [J].

Gainsford, T ;

Willson, TA ;

Metcalf, D ;

Handman, E ;

McFarlane, C ;

Ng, A ;

Nicola, NA ;

Alexander, WS ;

Hilton, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) :14564-14568

[10] WEIGHT-REDUCING EFFECTS OF THE PLASMA-PROTEIN ENCODED BY THE OBESE GENE [J].

HALAAS, JL ;

GAJIWALA, KS ;

MAFFEI, M ;

COHEN, SL ;

CHAIT, BT ;

RABINOWITZ, D ;

LALLONE, RL ;

BURLEY, SK ;

FRIEDMAN, JM .

SCIENCE, 1995, 269 (5223) :543-546