Solving the membrane protein folding problem

被引：350

作者：

Bowie, JU ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Inst Mol Biol, UCLA DOE Ctr Genom & Proteom, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

NATURE | 2005年 / 438卷 / 7068期

关键词：

D O I：

10.1038/nature04395

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

One of the great challenges for molecular biologists is to learn how a protein sequence defines its three-dimensional structure. For many years, the problem was even more difficult for membrane proteins because so little was known about what they looked like. The situation has improved markedly in recent years, and we now know over 90 unique structures. Our enhanced view of the structure universe, combined with an increasingly quantitative understanding of fold determination, engenders optimism that a solution to the folding problem for membrane proteins can be achieved.

引用

页码：581 / 589

页数：9

共 93 条

[1] ACTIVATION OF BEEF-HEART CYTOCHROME-C-OXIDASE BY CARDIOLIPIN AND ANALOGS OF CARDIOLIPIN [J].