A census of human cancer genes

被引：2359

作者：

Futreal, PA

Coin, L

Marshall, M

Down, T

Hubbard, T

Wooster, R

Rahman, N

Stratton, MR

机构：

[1] Wellcome Trust Sanger Inst, Human Genome Anal Grp, Canc Genome Project, Hinxton CB10 1SA, Cambs, England

[2] Wellcome Trust Sanger Inst, Pfam Grp, Hinxton CB10 1SA, Cambs, England

[3] Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 03期

关键词：

D O I：

10.1038/nrc1299

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A central aim of cancer research has been to identify the mutated genes that are causally implicated in oncogenesis ('cancer genes'). After two decades of searching, how many have been identified and how do they compare to the complete gene set that has been revealed by the human genome sequence? We have conducted a 'census' of cancer genes that indicates that mutations in more than 1% of genes contribute to human cancer. The census illustrates striking features in the types of sequence alteration, cancer classes in which oncogenic mutations have been identified and protein domains that are encoded by cancer genes.

引用

页码：177 / 183

页数：7

共 43 条

[1] Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins [J].