Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

被引：374

作者：

Amundson, SA ^{[1
]}

Myers, TG

Fornace, AJ

机构：

[1] NCI, Div Basic Sci, NIH, Bethesda, MD 20892 USA

[2] NCI, Dev Therapeut Program, NIH, Bethesda, MD 20892 USA

来源：

ONCOGENE | 1998年 / 17卷 / 25期

关键词：

cell cycle; stress-response; p53; functional genomics;

D O I：

10.1038/sj.onc.1202576

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tumor suppressor gene p53 plays a major role in regulation of the mammalian cellular stress response, in part through the transcriptional activation of genes involved in cell cycle control, DNA repair, and apoptosis. Many factors contribute to control of the activation of p53, and the downstream response to its activation may also vary depending on the cellular environment or other modifying factors in the cell. The complexity of the p53 response makes this an ideal system for application of newly emerging rapid throughput analysis techniques and informatics analysis.

引用

页码：3287 / 3299

页数：13

共 212 条

[1] P53 CONTROLS BOTH THE G(2)/M AND THE G(1) CELL-CYCLE CHECKPOINTS AND MEDIATES REVERSIBLE GROWTH ARREST IN HUMAN FIBROBLASTS [J].