Opinion - Death-defying immunity: do apoptotic cells influence antigen processing and presentation?

被引：224

作者：

Albert, ML ^{[1
]}

机构：

[1] Inst Pasteur, Lab Immunobiol Cellules Dendrit, INSERM AVEN0201, F-75724 Paris 15, France

来源：

NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 03期

关键词：

D O I：

10.1038/nri11308

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The clearance of apoptotic cells has been paid much attention for its role not only in tissue homeostasis, but also as a source of antigen for immune tolerance and activation. The complexity of this process has been borne out by the many receptor families and signalling pathways involved; however, an important aspect of the biology has so far been overlooked. This article explores the possible immunological instructions that are delivered by dying cells, as influenced by the specific execution pathways that are active during programmed cell death.

引用

页码：223 / 231

页数：9

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