Effects of somatosensory stimulation on use-dependent plasticity in chronic stroke

被引:99
作者
Sawaki, L
Wu, CWH
Kaelin-Lang, A
Cohen, LG
机构
[1] Natl Inst Neurol Disorders & Stroke, Human Cort Physiol Sect, NIH, Bethesda, MD USA
[2] Wake Forest Univ, Program Rehabil, Dept Neurol, Winston Salem, NC USA
[3] Univ Hosp Inselspital, Motor Lab, Dept Neurol, Bern, Switzerland
[4] Univ Hosp Inselspital, Movement Disorders Ctr, Bern, Switzerland
关键词
nerve stimulation; neuronal plasticity; stroke; stimulation; transcranial magnetic;
D O I
10.1161/01.STR.0000195130.16843.ac
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose - There is a need to develop strategies to enhance the beneficial effects of motor training, including use-dependent plasticity (UDP), in neurorehabilitation. Peripheral nerve stimulation (PNS) modulates motor cortical excitability in healthy humans and could influence training effects in stroke patients. Methods - We compared the ability of PNS applied to the (1) arm, (2) leg, and (3) idle time to influence training effects in the paretic hand in 7 chronic stroke patients. The end point measure was the magnitude of UDP. Results - UDP was more prominent with arm stimulation (increased by 22.8%) than with idle time (by 2.9%) or leg stimulation (by 6.4%). Conclusions - PNS applied to the paretic limb paired with motor training enhances training effects on cortical plasticity in stroke patients.
引用
收藏
页码:246 / 247
页数:2
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