Isoindolinone enantiomers having affinity for the dopamine D4 receptor

被引:215
作者
Belliotti, TR [1 ]
Brink, WA [1 ]
Kesten, SR [1 ]
Rubin, JR [1 ]
Wustrow, DJ [1 ]
Zoski, KT [1 ]
Whetzel, SZ [1 ]
Corbin, AE [1 ]
Pugsley, TA [1 ]
Heffner, TG [1 ]
Wise, LD [1 ]
机构
[1] Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Ann Arbor, MI 48105 USA
关键词
D O I
10.1016/S0960-894X(98)00252-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
PD 108635 (1) was identified as a potent dopamine D-4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D-4 affinity. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1499 / 1502
页数:4
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