Novel methods to monitor antigen-specific cytotoxic T-cell responses in cancer immunotherapy

被引：76

作者：

Romero, P

Cerottini, JC

Waanders, GA

机构：

[1] CHU Vaudois, Ludwig Inst Canc Res, Div Clin Oncoimmunol, CH-1011 Lausanne, Switzerland

[2] Diagnocure, Tumor Immunol & Vaccine Dev, St Foy, PQ G1V 2K8, Canada

来源：

MOLECULAR MEDICINE TODAY | 1998年 / 4卷 / 07期

关键词：

D O I：

10.1016/S1357-4310(98)01280-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Monitoring cytotoxic T lymphocyte (CTL) responses to tumor antigens that have been defined at the molecular level has become essential to assess novel approaches to the specific immunotherapy of cancer. Nevertheless, because of the low affinity of the interactions between T-cell receptors and their ligands, there are no straightforward, well-standardized methods to meet this' need. In this review, we describe several novel methods to track antigen-specific CTL responses.

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页码：305 / 312

页数：8

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