Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients

被引：88

作者：

Dalal, MA

Schuld, A

Haack, M

Uhr, M

Geisler, P

Eisensehr, I

Noachtar, S

Pollmächer, T

机构：

[1] Max Planck Inst Psychiat, D-80804 Munich, Germany

[2] Univ Regensburg, Dept Psychiat, D-8400 Regensburg, Germany

[3] Univ Munich, Dept Neurol, D-8000 Munich, Germany

来源：

NEUROLOGY | 2001年 / 56卷 / 12期

关键词：

D O I：

10.1212/WNL.56.12.1749

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Deficient orexin signaling has been shown to cause narcolepsy-like conditions in animals. In human narcolepsy, CSF levels of orexin A (hypocretin-1) were reported to be low in most cases. The authors measured CSF and plasma orexin A levels in patients with narcolepsy and in controls. Confirming earlier studies, they found CSF orexin A levels to be extremely low in patients with narcolepsy. However, plasma orexin A levels did not differ from those observed in controls. These results suggest that orexin deficiency in patients with narcolepsy is a phenomena restricted to the CNS.

引用

页码：1749 / 1751

页数：3

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