The role of microglia and myeloid immune cells in acute cerebral ischemia

被引：210

作者：

Benakis, Corinne ^{[1
]}

Garcia-Bonilla, Lidia ^{[1
]}

Iadecola, Costantino ^{[1
]}

Anrather, Josef ^{[1
]}

机构：

[1] Weill Cornell Med Coll, Feil Family Brain & Mind Res Inst, 407 East 61st St,RR-409, New York, NY 10065 USA

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2015年 / 8卷

基金：

美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

cerebral ischemia; monocytes; microglia; neutrophils; myeloid cells; tissue macrophages; MONOCYTE CHEMOATTRACTANT PROTEIN-1; CENTRAL-NERVOUS-SYSTEM; REGULATORY T-CELLS; COLONY-STIMULATING FACTOR; NITRIC-OXIDE SYNTHASE; BONE-MARROW; BLOOD MONOCYTES; BRAIN-INJURY; EXPERIMENTAL STROKE; FOCAL ISCHEMIA;

D O I：

10.3389/fncel.2014.00461

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The immune response to acute cerebral ischemia is a major contributor to stroke pathobiology. The inflammatory response is characterized by the participation of brain resident cells and peripheral leukocytes. Microglia in the brain and monocytes/neutrophils in the periphery have a prominent role in initiating, sustaining and resolving post-ischemic inflammation. In this review we aim to summarize recent literature concerning the origins, fate and role of microglia, monocytes and neutrophilsin models of cerebral ischemia and to discuss their relevance for human stroke.

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页数：16

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