Mesenchymal stem cells:: heading into the clinic

被引：157

作者：

Koç, ON ^{[1
]}

Lazarus, HM ^{[1
]}

机构：

[1] Case Western Reserve Univ, Ireland Canc Ctr, Dept Med, Cleveland, OH 44106 USA

来源：

BONE MARROW TRANSPLANTATION | 2001年 / 27卷 / 03期

关键词：

human bone marrow; stroma; hematopoietic progenitor cells; stem cells; mesenchymal stem cells; allogeneic and autologous transplantation;

D O I：

10.1038/sj.bmt.1702791

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

In recent Sears, there has been an increasing interest in non-hematopoietic pluripotent progenitor cells that are found in the bone marrow. Mesenchymal stem cells (MSCs) are the first non-hematopoietic progenitors to be isolated from the bone marrow and extensively characterized. In addition to their ability to support hematopoiesis, MSCs can differentiate into osteocytes, chondrocytes, tenocytes, adipocytes and smooth muscle cells, This article will review our current understanding of bone marrow stroma and MSCs and their potential therapeutic role in the setting of hematopoietic stem cell transplantation.

引用

页码：235 / 239

页数：5

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