Inhibitory effect of kaurane type diterpenoids from Acanthopanax koreanum on TNF-α secretion from trypsin-stimulated HMC-1 cells

被引：26

作者：

Cai, XF

Shen, G

Dat, NT

Kang, OH

Lee, YM

Lee, JJ

Kim, YH ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan 540749, Cheonbuk, South Korea

[3] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2003年 / 26卷 / 09期

关键词：

Acanthopanax koreanum; kaurane type diterpenoid; inhibitory effect; TNF-alpha scretion;

D O I：

10.1007/BF02976683

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five known kaurane type diterpenoids, 16alphaH,17-isovaleryloxy-ent-kauran-19-oic acid (1), 16alpha-hydroxy-17-isovaleryloxy-ent-kauran-19-oic acid (2), paniculoside-IV (3), 16alpha-hydroxy-ent-kauran-19-oic acid (4), and ent-kaur-16-en-19-oic acid (5) were isolated from the root of Acanthopanax koreanum by repeated column chromatography and reversed phase preparative HPLC. The structures of these compounds were established from physicochemical and spectral data. Among the isolated compounds 16alphaH, 17-isovaleryloxy-ent-kauran-19-oic acid (1) showed potent inhibitory activity (IC(50)value, 16.2 uM) on TNF-alpha secretion from HMC-1, a trypsin-stimulated human leukemic mast cell line.

引用

页码：731 / 734

页数：4

共 15 条

[1] Mast cells are an important cellular source of tumour necrosis factor α in human intestinal tissue [J].